Publications by authors named "P Norberg"
Article Synopsis
- The study analyzes the genomic signatures of 2,768 eukaryotic viral species from 105 families to understand their unique characteristics and evolutionary pressures.
- It finds that most viruses have specific genomic signatures that can vary significantly even among closely related species, particularly in dsDNA viruses and those with larger genomes.
- The research highlights notable differences between viral genomic signatures and those of host cells, indicating evolutionary selection pressures that could influence areas like synthetic biology and vaccine development.
Diagnostic performance of a novel deep learning attenuation correction software for MPI using a cardio dedicated CZT camera. Experience in the clinical practice.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
January 2024
Article Synopsis
- A study evaluated a new software (DLACS) designed to improve the accuracy of myocardial perfusion imaging (MPI) for diagnosing coronary artery disease (CAD) in high-risk patients using a specialized camera.
- The research involved 300 patients, analyzing the accuracy of MPI with and without DLACS in comparison to invasive coronary angiography for CAD diagnosis.
- Results showed that DLACS increased diagnostic accuracy from 87% to 90%, emphasizing better specificity and positive predictive value, which reduces false positives and improves overall performance.
Members of the family have enveloped, spherical virions with characteristic complex structures consisting of symmetrical and non-symmetrical components. The linear, double-stranded DNA genomes of 125-241 kbp contain 70-170 genes, of which 43 have been inherited from an ancestral herpesvirus. In general, herpesviruses have coevolved with and are highly adapted to their hosts, which comprise many mammalian, avian and reptilian species.
View Article and Find Full Text PDFBackground: Alignment-free methods are a popular approach for comparing biological sequences, including complete genomes. The methods range from probability distributions of sequence composition to first and higher-order Markov chains, where a k-th order Markov chain over DNA has [Formula: see text] formal parameters. To circumvent this exponential growth in parameters, variable-length Markov chains (VLMCs) have gained popularity for applications in molecular biology and other areas.
View Article and Find Full Text PDFBackground: Infection with varicella zoster virus (VZV) may involve different central nervous system (CNS) manifestations, including meningitis, encephalitis, and vasculitis. In cases in which otherwise healthy individuals are affected, an inborn error of immunity may underlie increased susceptibility or severity of infection.
Methods: We collected a cohort of 17 adults who experienced VZV encephalitis and performed whole exome sequencing.