Publications by authors named "P Noelle Scully"
Background: Extracellular volume fraction (ECV) is a marker for myocardial fibrosis and infiltration, can be quantified using cardiac computed tomography (ECV), and has prognostic utility in several diseases. This study aims to map out regional differences in ECV to obtain greater insights into the pathophysiological mechanisms of ECV expansion and its clinical implications.
Methods: Three prospective cohorts were included: patients with aortic stenosis (AS) and coexisting AS and transthyretin cardiac amyloidosis were referred for a transcatheter aortic valve replacement and had ECG-gated CT angiography and Technetium-99m-labelled 3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy to differentiate between the 2 cohorts.
Article Synopsis
- Crouzon syndrome with acanthosis nigricans (CAN) results from a specific genetic mutation and is characterized by craniosynostosis, midface hypoplasia, and hyperkeratotic skin disorders.
- A study reviewed six patients diagnosed with CAN over 36 years, examining their medical histories and challenges related to speech, language, hearing, and feeding.
- Findings indicated that all patients experienced significant complications such as airway management needs, feeding difficulties, and hearing loss, with common issues including low weight and communication disorders.
Article Synopsis
- Cardiac involvement in idiopathic inflammatory myopathies (IIM) can lead to worse clinical outcomes, making early detection critical.
- Traditional tests like blood biomarkers, ECGs, and echocardiograms are widely available but often lack accuracy for identifying heart issues.
- Advanced imaging techniques like cardiovascular magnetic resonance (CMR) and 18F-FDG-PET/CT are improving diagnosis of myocarditis, with CMR-based Lake Louise Criteria and endomyocardial biopsy being key for accurate assessment.
Introduction: Artificial intelligence (AI) may benefit pediatric healthcare, but it also raises ethical and pragmatic questions. Parental support is important for the advancement of AI in pediatric medicine. However, there is little literature describing parental attitudes toward AI in pediatric healthcare, and existing studies do not represent parents of hospitalized children well.
View Article and Find Full Text PDFAccurate and rapid point-of-care (PoC) diagnostics are critical to the control of the COVID-19 pandemic. The current standard for accurate diagnosis of SARS-CoV-2 is laboratory-based reverse transcription polymerase chain reaction (RT-PCR) assays. Here, a preliminary prospective performance evaluation of the QuantuMDx Q-POC SARS-CoV-2 RT-PCR assay is reported.
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