Publications by authors named "P Niscola"
Article Synopsis
- Acute myeloid leukemia (AML) is a complex type of blood cancer mainly affecting older adults, who often have poor outcomes due to their overall health and other medical issues.
- Recent studies have uncovered important molecular and biological factors related to AML, leading to improved treatment options for older patients.
- The article reviews the latest advancements in understanding and treating AML, focusing on how these developments are changing care for older adults with the disease.
The achievement of complete remission (CR) is crucial for acute myeloid leukemia (AML) patients undertaking curative therapy, but relapse often occurs within months, highlighting the need for strategies to prolong disease-free survival (DFS). Our phase III study compared the efficacy and safety of azacitidine (AZA) to best supportive care (BSC) in elderly AML patients who achieved CR following intensive induction and consolidation therapy. This ancillary study (QOL-ONE Trans-2) evaluated biological changes in bone marrow using Next-Generation Sequencing (NGS).
View Article and Find Full Text PDFMyelodysplastic syndromes/neoplasms (MDSs) encompass a range of hematopoietic malignancies, commonly affecting elderly individuals. Molecular alterations in the hematopoietic stem cell compartment drive disease pathogenesis. Recent advancements in genomic profiling have provided valuable insights into the biological underpinnings of MDSs and have expanded therapeutic options, particularly for specific molecularly defined subgroups.
View Article and Find Full Text PDF