Publications by authors named "P Niering"
Resveratrol (trans-3,5,4',-trihydroxystilbene) is assumed to possess cancer-preventive and cancer-therapeutic properties. The aim of this project was to analyze cellular effects of resveratrol in metabolically active H4IIE rat hepatoma cells in comparison to metabolically poorly active C6 rat glioma cells. Resveratrol is rapidly taken up by both cell types and acts as a potent intracellular antioxidant.
View Article and Find Full Text PDFFlavonoids are ubiquitous substances in fruits and vegetables. Among them, the flavonol kaempferol contributes up to 30% of total dietary flavonoid intake. Flavonoids are assumed to exert beneficial effects on human health, e.
View Article and Find Full Text PDFDietary flavonoids possess a wide spectrum of biochemical and pharmacological actions and are assumed to protect human health. These actions, however, can be antagonistic, and some health claims are mutually exclusive. The antiapoptotic actions of flavonoids may protect against neurodegenerative diseases, whereas their proapoptotic actions could be used for cancer chemotherapy.
View Article and Find Full Text PDFPhytochemical investigation of plants used in traditional Indonesian medicine (Jamu) yielded lignans (pinoresinol, 9 alpha-hydroxypinoresinol and salicifoliol), flavonoids (3-O-beta-(D)-glucopyranosyl-(1-->6)-beta-(D)-glucopyranosylkaempferol, luteolin and apigenin) and coumarins (coumarin, 8-hydroxycoumarin and 5-hydroxycoumarin). The beneficial effects of the respective plants for human health are thought to be associated with antioxidative activity. In the present study, the antioxidative capacity of the isolated compounds was determined in an in-vitro assay.
View Article and Find Full Text PDFArticle Synopsis
- Polyphenols, like luteolin, are common in our diet and have beneficial health effects, but high concentrations can cause toxicity.
- In H4IIE rat hepatoma cells, luteolin triggered apoptosis, evident by markers such as DNA ladder formation and activation of various caspases, with significant increases in caspase-3/7 and caspase-9 activity over 24 hours.
- Luteolin also showed a prooxidative effect, indicated by increased malondialdehyde release and DNA strand breaks, supporting the idea that it activates the mitochondrial pathway of apoptosis possibly through DNA damage.