Publications by authors named "P Niels Christensen"
Background: The cornerstone of low anterior resection syndrome (LARS) treatment is self-management, which requires patient engagement. Colorectal surgeons and nurses may use patient-generated health data (PGHD) to help guide patients in their use of self-management strategies for LARS. However, the perspectives of LARS experts on the use of PGHD remain largely unexplored.
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- Bacterial membranes are influenced by various evolutionary factors, with the enzyme MprF playing a crucial role in modifying membrane lipids.
- MprF synthesizes lysyl-phosphatidylglycerol (Lys-PG) and a new lipid, lysyl-glucosyl-diacylglycerol (Lys-Glc-DAG), prompting further investigation of MprF's substrate specificity in other bacteria.
- Using protein sequence analysis and machine learning, researchers discovered additional MprF products and the presence of diglucosyl-diacylglycerol (Glc-DAG) as a new substrate, highlighting the enzyme’s evolutionary significance across different bacterial species.
Background: Sperm DNA damage is associated with reduced male fertility after natural conception and intrauterine insemination. However, the impact on in vitro fertilization (IVF) and especially intracytoplasmic sperm injection (ICSI) treatments is still unclear. Few studies have focused on the intra-individual variation in DFI even though it may have an important role to play in terms of detection of thresholds and for misclassification rates.
View Article and Find Full Text PDFAerobic Energy Turnover and Exercise Economy Profile During Race Simulation in a World-Record-Breaking Male Full-Distance Triathlete.
Int J Sports Physiol Perform
January 2025
Article Synopsis
- The study investigates the metabolism and exercise efficiency of a top-tier triathlete during extended race simulations lasting over 4 hours to refine training and nutrition strategies.
- The triathlete, preparing for Challenge Roth 2023, underwent two simulated races that included cycling and running, with frequent physiological assessments to measure factors like oxygen uptake and heart rate.
- Results indicated that while carbohydrate utilization was key for energy, the triathlete maintained strong aerobic performance and stable cycling efficiency, though running efficiency slightly declined over time.
Over the last four years, each successive wave of the COVID-19 pandemic has been caused by variants with mutations that improve the transmissibility of the virus. Despite this, we still lack tools for predicting clinically important features of the virus. In this study, we show that it is possible to predict the PCR cycle threshold (Ct) values from clinical detection assays using sequence data.
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