(+)-Catechin in a 1:2 Complex with Lysine Inhibits Cancer Cell Migration and Metastatic Take in Mice.

Metastasis is of dismal prognosis for cancer patients, but recent evidence in mouse models of cancer shows that metastasis prevention is a reachable clinical objective. These experiments indicate that altered mitochondrial activities are associated with the metastatic phenotype. Mitochondrial transfer from metastatic to non-metastatic cells can indeed transfer the metastatic phenotype, and metastatic progenitor cells differ from other cancer cells by a higher sublethal production of mitochondrial reactive oxygen species (ROS).

Vessel wall modification in venous pathology. Application to the study of phlebotonic drugs.

Pathophysiological investigation of varicose veins show extensive metabolic perturbation and structural parietal changes. Oxygen consumption is reduced more than three-fold while levels of activity of proteolytic enzymes from lysosomes are significantly raised. Connective tissue in the venous wall undergoes profound deterioration, with a decrease in collagen fibrils and an increase in proteoglycans.

Effect of milacemide, a glycinamide derivative, on the rat brain gamma-aminobutyric acid system.

Milacemide (CP 1552 S, 2-n-pentylaminoacetamide), a drug with anti-epileptic potency, increases the gamma-aminobutyric acid (GABA) content specifically in the substantia nigra of rat brain. The effect is dose-related from 25 to 100 mg/kg p.o.

Determination of individual hydroxyethyl rutosides in various animal body fluids by thin-layer chromatography and scanning densitometry.

A method is described for the accurate determination in plasma of the beta-hydroxyethylrutosides by measurement of the fluorescence of their borocitrate complexes by scanning densitometry following separation by thin-layer chromatography. A modification is also described for estimation of individual hydroxyethylrutosides and their glucuronide conjugates in samples of bile and urine.