Publications by authors named "P Nicolau-Neto"
Article Synopsis
- Homeobox genes are important for organ development and differentiation, and in humans, they are divided into four clusters (HOXA, HOXB, HOXC, HOXD).
- This study focused on the role of these genes in esophageal squamous cell carcinoma (ESCC), finding that while mutations were rare, seven specific homeobox genes were significantly different in ESCC tissues compared to non-cancerous ones.
- The study revealed that these genes' dysregulation may affect cancer pathways and is linked to poor survival rates, suggesting their potential as prognostic biomarkers and targets for new therapies.
Background: Laryngeal squamous cell carcinoma (LSCC) is the second most frequent head and neck tumor. Prognosis of patients with LSCC has not improved in recent decades, showing a need for the identification of prognostic biomarkers and new therapeutic targets. Recently, we showed that ALCAM overexpression was associated with glottic LSCC prognosis.
View Article and Find Full Text PDFBackground: In breast cancer (BC), hypoxia is associated with poor prognosis. Protein Salvador homolog 1 (SAV1) acts as a tumor suppressor and is downregulated in the cancer cells. However, there is limited data on the expression profile of SAV1 and its importance in BC.
View Article and Find Full Text PDFGastroesophageal cancer (GEC) is an aggressive disease characterized by a high frequency of metastasis and poor overall survival rates. GEC presents HER2 overexpression in 5 to 25% of tumors eligible for HER2-targeted therapy. HER2 evaluation requires protein levels and copy number alteration analyses by immunohistochemistry (IHC) and in situ hybridization (FISH or SISH), respectively.
View Article and Find Full Text PDFArticle Synopsis
- Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer due to late detection and ineffective treatments, highlighting the urgent need for better diagnostics and new therapeutic targets.
- Research on the IL6 gene showed that its expression is significantly higher in ESCC tumors compared to non-tumoral surrounding tissue, indicating its potential role in cancer development.
- The study suggests that therapies targeting IL6 could be beneficial for ESCC treatment, and it identifies the mRNA expression levels as a promising biomarker for early detection of the disease.*