Publications by authors named "P Neslihan Taslı"
Article Synopsis
- * This study investigates the protective effects of extracellular vesicles (NEVs) derived from neural progenitor cells that overexpress the NRF2 gene against cisplatin-induced neurotoxicity, utilizing various functional and molecular assays to assess their impact on post-mitotic neurons.
- * Findings indicate that NEVs provide dose-dependent protection by maintaining antioxidant levels, reducing reactive oxygen species (ROS), and preserving mitochondrial function, suggesting a potential path for neuroprotection via the NRF2/ARE pathway. *
Article Synopsis
- Researchers explored the therapeutic potential of exosomes derived from foreskin-derived mesenchymal stromal cells for treating androgenetic alopecia in men, aiming to improve hair density and patient satisfaction.
- The study involved 30 male participants, aged 22 to 65, who received exosome injections and were assessed for hair density and satisfaction at multiple intervals.
- Results showed a significant increase in hair density at weeks 4 and 12, with enhanced patient satisfaction and no reported side effects from the treatment.
Extracellular vesicles are secreted by all eukaryotic cells and they have an important role in intercellular signaling. Plant extracellular vesicles (PEVs) are a novel area of research that has gained attention due to their potential implications in biomolecule transport and therapeutic applications. PEVs are lipid bilayer-enclosed structures that contain a diverse cargo of biomolecules such as proteins and lipids.
View Article and Find Full Text PDFAs an element of the cellular signaling systems, extracellular vesicles (EVs) exhibit many desirable traits for usage as targeted delivery vehicles. When administered, EVs cause little to no toxic or immune response, stay in circulation for longer periods compared to synthetic carriers, preferentially accumulate in tissues that are the same or similar to their cell-of-origin and can pass through the blood-brain barrier. Combined, these traits make neural EVs a particularly promising tool for delivering drugs to the brain.
View Article and Find Full Text PDFObjectives: The present study aimed to (1) investigate biocompatibility and cytotoxicity of pulp-capping materials on viability of human dental pulp stem cells (hDPSCs); (2) determine angiogenic, odontogenic, and osteogenic marker mRNA expressions; and (3) observe changes in surface morphology of the hDPSCs using scanning electron microscopy (SEM).
Methods: Impacted third molars were used to isolate the hDPSCs, which were treated with extract-release fluids of the pulp-capping materials (Harvard BioCal-Cap, NeoPUTTY MTA, TheraCal LC, and Dycal). Effects of the capping materials on cell viability were assessed using 3-(4,5-di-methyl-thiazol-2-yl)-5-(3-carboxy-methoxy-phenyl)-2-(4-sulfo-phenyl)-2H-tetrazolium (MTS) assay and the apoptotic/necrotic cell ratios and reactive oxygen species (ROS) levels from flow cytometry.