Publications by authors named "P Neau"
Article Synopsis
- Still's disease (SD) is an autoinflammatory condition with varying forms, and this study aimed to compare adult-onset SD (AOSD) and systemic juvenile idiopathic arthritis (sJIA) while identifying prognosis.
- Researchers analyzed data from 238 patients, finding that 64% had AOSD, with symptoms like sore throat and muscle pain being more common in this group, as well as higher levels of liver enzymes and inflammatory markers.
- Key findings indicated that symptoms like fever and skin rash are linked to better recovery chances, while high lactate dehydrogenase levels suggest a poorer prognosis, supporting the idea that SD can evolve into chronic arthritis if not treated promptly.
Article Synopsis
- Distinguishing macrophage activation syndrome (MAS) from a simple flare of Still's disease (SD) is complex; researchers aimed to identify clinical features and outcomes related to MAS and its predictive factors in SD patients.
- In a study involving 206 SD patients, 20 (9.7%) experienced MAS, which presented more often with symptoms like hepatomegaly and neurological issues, alongside higher rates of cytopenias, liver problems, and abnormal coagulation.
- High serum ferritin levels, specifically above 3500 μg/L, demonstrated strong predictive value for MAS development, with specific factors like neurological symptoms and coagulopathy aiding in early detection.
Human African Trypanosomiasis (HAT or sleeping sickness) is a life-threatening neglected tropical disease that is endemic in 36 sub-Saharan African countries. Until recently, treatment options were limited and hampered by unsatisfactory efficacy, toxicity, and long and cumbersome administration regimens, compounded by infrastructure inadequacies in the remote rural regions worst affected by the disease. Increased funding and awareness of HAT over the past two decades has led to a steady decline in reported cases (<1000 in 2018).
View Article and Find Full Text PDFThe gene encoding the urea transporter of human erythrocytes (HUT11 clone) has been cloned recently (Olives, B., Neau, P., Bailly, P.
View Article and Find Full Text PDFA rapid passive urea transport has been previously described in the mammalian renal inner medullary collecting duct epithelial cells and in mammalian erythrocytes. Recently, a vasopressin-regulated urea transporter (UT2) has been cloned from a rabbit kidney medullary cDNA library (You, G., Smith, C.
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