The modularity of transcriptional enhancers is central to our understanding of morphological evolution, allowing specific changes to a gene expression pattern component, without affecting others. Enhancer modularity refers to physically separated stretches of regulatory sequence producing discrete spatiotemporal transcriptional activity. This concept stems from assays that test the sufficiency of a DNA segment to drive spatial reporter expression resembling that of the corresponding gene.
View Article and Find Full Text PDFThe search for Earth-like exoplanets with the Doppler radial velocity (RV) technique is an extremely challenging and multifaceted precision spectroscopy problem. Currently, one of the limiting instrumental factors in reaching the required long-term 10 level of radial velocity precision is the defect-driven subpixel quantum efficiency (QE) variations in the large-format detector arrays used by precision echelle spectrographs. Tunable frequency comb calibration sources that can fully map the point spread function (PSF) across a spectrograph's entire bandwidth are necessary for quantifying and correcting these detector artifacts.
View Article and Find Full Text PDFIndian J Pathol Microbiol
June 2024
Odontomes are the most common benign odontogenic tumors of the jaw which are usually slow-growing and non-aggressive. They are generally asymptomatic and diagnosed during routine radiographic investigations and are mostly associated with tooth eruption disturbances. The present case series report covers seven cases of odontomes discussing on clinical, radiographic, and histopathologic features (ground section and decalcification) along with a brief review of the literature.
View Article and Find Full Text PDFObjective: Despite high in-hospital mortality, the epidemiology of prehospital suspected sepsis presentations is not well described. This retrospective cohort study aimed to quantify the burden of such presentations, and to determine whether such a diagnosis was independently associated with longer-term mortality.
Methods: Retrospective, observational population-based cohort study examining all adult prehospital presentations in Victoria, between January 2015 and June 2019, who required subsequent in-hospital assessment.
Intensive care unit-acquired weakness (ICU-AW) is a serious complication in critically ill patients. Therefore, timely and accurate diagnosis and monitoring of ICU-AW are crucial for effectively preventing its associated morbidity and mortality. This article provides a comprehensive review of ICU-AW, focusing on the different methods used for its diagnosis and monitoring.
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