Publications by authors named "P Nappa"
Real-life effectiveness and safety of baricitinib in patients with severe alopecia areata: A 24-week Italian study.
J Eur Acad Dermatol Venereol
September 2024
Background: Alopecia areata is an autoimmune condition characterized by rapid hair loss in the scalp, eyebrows and eyelashes, for which treatments are limited. Baricitinib, an oral inhibitor of Janus kinases 1 and 2, has been recently approved to treat alopecia areata.
Materials And Methods: We conducted a retrospective study involving 23 medical centres across Italy, enrolling patients affected by severe alopecia areata (SALT >50), for more than 6 months.
Article Synopsis
- * Researchers found that 8 patients had autosomal recessive ichthyosis, while others had X-linked ichthyosis, with a total of 24 disease-causing alleles identified, including 8 novel variants.
- * The findings help enhance early diagnosis and classification of ichthyosis patients, broadening the understanding of the genetic and phenotypic diversity of inherited ichthyosis disorders.
Article Synopsis
- The study investigates the dermatological manifestations of COVID-19 in children, particularly noting the prevalence of chilblain-like lesions among infected and non-infected patients, attributed to a pronounced interferon response in younger individuals.
- Conducted over six months, the research involved 137 patients aged 1 to 18 from 23 Italian dermatological units, who exhibited a variety of skin lesions primarily on the feet.
- Results showed diverse skin symptoms, with many experiencing concomitant systemic symptoms, highlighting the complex interplay of dermatological and respiratory issues related to COVID-19 in children.