Publications by authors named "P Nagesh"
Maize ( L.) is a globally important crop, thriving across diverse environments. Breeding maize inbreds with good combining ability for stable yields under both optimal and stress-prone conditions has been successful.
View Article and Find Full Text PDFBackground: High-risk strains of HPV are known to cause cervical cancer. Multiple clinical studies have emphasized that smoking and drinking are critical risk factors for cervical cancer and its high-grade precursors. In this study, we investigated if smoking and/or drinking augment the molecular mechanisms of cervical carcinogenesis and defined a potential therapeutic approach for their attenuation.
View Article and Find Full Text PDFBackground/aims: After 9/11, multiple government agencies instituted programs aimed at developing medical radiation countermeasures (MRCs) for two syndromes lethal within weeks of a limited nuclear attack; the hematopoietic-acute radiation syndrome (H-ARS) and the higher-dose gastrointestinal-acute radiation syndrome (GI-ARS). While re-purposing drugs that enhance marrow repopulation treats H-ARS, no mitigator protects GI tract.
Methods: We recently reported anti-ceramide 6B5 single-chain variable fragment (scFv) pre-treatment abrogates ongoing small intestinal endothelial apoptosis to rescue Lgr5 stem cells, preventing GI-ARS lethality in C57B/L6J mice.
Article Synopsis
- The export and transformation of agrochemicals, particularly S-Metolachlor and its byproducts, threaten water quality and are influenced by climate changes.
- An integrated modeling framework was used to simulate different climate scenarios (dry, wet, high temperature) in Burgenland, Austria, affecting the degradation and transport of these substances in agricultural land.
- Results indicate that while a significant amount of S-Metolachlor is degraded under various conditions, extreme weather events can lead to increased retention and concentrations of its transformation products in water systems over time.
Article Synopsis
- Severe alcohol-associated hepatitis (AH) is a serious liver disease characterized by increased neutrophil infiltration, but the impact of alcohol on neutrophil function is still not fully understood.
- Researchers discovered that Bruton's tyrosine kinase (BTK) is elevated in neutrophils of AH patients and is activated by alcohol through TLR4 signaling, linked to liver damage.
- In mouse models, inhibiting BTK or knocking it out in specific immune cells reduced neutrophil activity and damage to the liver, suggesting that targeting BTK and its interaction with CD84 might offer new treatments for AH.