Publications by authors named "P Nadarajan"
Article Synopsis
- - Airway macrophages (AM) are key immune cells in the lungs that help protect against infections, making them important for targeted therapies aimed at enhancing immune responses.
- - The study investigates how different types of macrophages respond to signaling molecules (IFN-γ and IL-4) that represent immune responses in the lungs, finding that AM rely heavily on glycolysis for their functions, especially in cytokine production.
- - Results show that AM exhibit unique metabolic responses and functional plasticity compared to monocyte-derived macrophages (MDM), suggesting that AM could be effective targets for new inhaled treatments for lung diseases.
Article Synopsis
- Tissue-resident natural killer (trNK) cells are found in the human lung, and this study investigates their unique metabolic functions, which may play a role in their effectiveness as immune cells.
- Researchers analyzed human bronchoalveolar lavage fluid (BALF) and peripheral blood using flow cytometry and SCENITH to compare the phenotype and metabolism of NK cells in these locations, uncovering specific markers for trNK cells.
- The study discovered that lung NK cells have a significantly higher glycolytic capacity and are more reliant on glucose than those in peripheral blood, suggesting these trNK cells are better equipped to respond to challenges in the lung environment.
Exosomes, a class of extra cellular nano-sized vesicles (EVs), and their contents have gained attention as potential sources of information on tumor detection and regulatory drivers of tumor progression and metastasis. The effect of exosomes isolated from patients with an Epidermal Growth Factor Receptor ()-mutated adenocarcinoma on the promotion of epithelial-mesenchymal transition (EMT) and invasion were examined. Exosomes derived from serum of patients with -mutated non-small cell lung cancer (NSCLC) mediate the activation of the Phosphoinositide 3-kinase (PI3K)/AKT/ mammalian target of rapamycin (mTOR) pathway and induce an invasion through the up-regulation of matrix metalloproteinase-9 (MMP-9) in A549 cells.
View Article and Find Full Text PDFBackground: Prolonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS-13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of acute COVID-19. We hypothesized that VWF/ADAMTS-13 imbalance persists in convalescence together with endothelial cell (EC) activation and angiogenic disturbance.
View Article and Find Full Text PDF