Neutron capture therapy with gadopentetate dimeglumine: experiments on tumor-bearing rats.

Rationale And Objectives: The therapeutic effect of neutron capture therapy with the gadolinium (Gd) complex gadopentetate dimeglumine was studied in vivo in rats using a beam of thermal neutrons.

Methods: Rats with Jensen sarcomas 10-15 mm in diameter in their right thigh were irradiated with a thermal neutron beam that had fluences of 3.6 x 10(11) (20 min) or 5.

Relative biological effectiveness of proton medical beam at Moscow synchrotron determined by the Chinese hamster cells assay.

Purpose: Assessment of relative biological effectiveness (RBE) of the proton medical beam at Moscow synchrotron.

Methods And Materials: The study was performed at Moscow proton medical facility (Institute for Theoretical and Experimental Physics). Relative biological effectiveness of the synchrotron proton beam was assessed at the entry of the unmodulated 179 MeV beam and in the center of spread out Bragg peak (SOBP), from measurements of the survival of Chinese hamster cells (clone 431).