Publications by authors named "P N Suffys"
Article Synopsis
- A significant portion of the genome of studied strains has become pseudogenes, but their genetic similarity remains high, with over 99% identity among isolates globally.
- The research focused on comparing three strains of a pathogen, including a reference strain and two from Brazilian leprosy relapse patients, highlighting differences in genotype and interaction with human cells.
- Despite minimal genetic differences, the strains displayed notable phenotypic changes, impacting their growth and interaction with host cells, which could enhance understanding of leprosy's varied clinical outcomes.
A Genome-Focused Investigation Reveals the Emergence of a Strain Related to Multidrug-Resistant Tuberculosis in the Amazon Region of Brazil.
Emilyn Costa Conceição Johannes Loubser Arthur Emil Dos Santos Guimarães Abhinav Sharma Liliana Kokusanilwa Rutaihwa Philip Noel Suffys
Microorganisms
September 2024
Article Synopsis
- A study in Pará, Northern Brazil, identified a unique strain of multidrug-resistant tuberculosis (MDR-TB) called SIT2517/T1, with a focus on its transmission dynamics.
- Researchers utilized various genetic testing methods, including whole-genome sequencing, to analyze 28 isolates, confirming their distinct sublineage and highlighting discrepancies in drug resistance testing for some antibiotics.
- The findings indicated a high probability of direct transmission among these isolates in urban areas, emphasizing the necessity for increased tuberculosis genomic surveillance in the Brazilian Amazon.
Article Synopsis
- * This study aimed to analyze genetic variations (SNPs) related to the enzyme in a specific population, revealing that most individuals had slow or intermediate acetylation phenotypes.
- * Identifying these genetic profiles can lead to personalized treatment strategies that improve patient outcomes, reduce treatment costs, and prevent drug-resistant strains of tuberculosis.
Asthma is a chronic inflammatory respiratory condition, characterized by variable airflow limitation, leading to clinical symptoms such as dyspnea and chest tightness. These symptoms result from an underlying inflammatory process. The β2 agonists are bronchodilators prescribed for the relief of the disease.
View Article and Find Full Text PDFSpecies belonging to the complex (MKC) are frequently isolated from humans and the environment and can cause serious diseases. The most common MKC infections are caused by the species (), leading to tuberculosis-like disease. However, a broad spectrum of virulence, antimicrobial resistance and pathogenicity of these non-tuberculous mycobacteria (NTM) are observed across the MKC.
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