Publications by authors named "P N Stamati"
Article Synopsis
- The study explored the link between neuropsychiatric symptoms (NPS) and frontotemporal atrophy (FTA) in older adults without dementia, specifically looking at those with mild cognitive impairment (MCI) and cognitively unimpaired (CU) individuals.
- It was found that older adults with MCI and FTA had significantly higher odds of experiencing certain NPS such as elation, aberrant motor behavior, and apathy compared to those without FTA.
- Conversely, the analysis indicated that CU individuals did not show significantly elevated odds of NPS with FTA, suggesting that the relationship between FTA and NPS may primarily affect those with cognitive impairments.
This narrative review explores the current landscape of blood biomarkers in Frontotemporal dementia (FTD). Neurofilament light chain (NfL) may be useful in the differentiation of behavioral variant FTD from primary psychiatric disorders (PPDs) or dementia with Lewy bodies (DLB). In prodromal FTD and presymptomatic mutation carriers (, , ), elevated NfL may herald pheno-conversion to full-blown dementia.
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- The study aimed to determine how motor signs in older adults with mild cognitive impairment (MCI) can predict the onset of dementia with Lewy bodies (DLB), especially focusing on differences between sexes.
- Researchers analyzed data from individuals over 55 years old, assessing various motor signs like resting tremor and bradykinesia, and found that certain signs significantly increased the risk of developing DLB, particularly in women.
- Results indicated that masked facies and resting tremor raised the risk of DLB considerably in women compared to men, while other motor signs like rigidity and hypophonia impacted the risk of different types of dementia, but not all motor features correlated with dementia risk.
Alzheimer's Disease (AD) is a progressive neurodegenerative disease and the main cause of dementia. Its etiology remains largely unclear, though genetic and environmental factors appear to confer susceptibility to AD development. This study assessed the role of ATP-binding Cassette A Subfamily 7 () genetic polymorphisms, as ongoing research suggests they have a role in the development of AD.
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- - The study aimed to explore cognitive deficits during transient global amnesia (TGA) episodes, discovering that impairments extend beyond just episodic memory.
- - Researchers reviewed 1302 articles, ultimately including 17 in their analysis, and found that TGA patients experience significant issues with spatiotemporal awareness, anterograde amnesia, and working memory during acute episodes.
- - Although many cognitive functions remain normal, recovery typically starts with spatiotemporal orientation, followed by working and semantic memory retrieval, while episodic memory issues may last longer, with subtle memory deficits possible even after 24 hours.