Internalization of extracellular vesicles of cancer patients by peripheral blood mononuclear cells during polychemotherapy: connection with neurotoxicity.

Extracellular vesicles (EVs), exhibiting their functional activity after internalization by recipient cells, are involved in the pathogenesis of drug-induced polyneuropathy (DIPN), a common complication of antitumor therapy. In this work, the internalization of EVs obtained from colorectal cancer patients undergoing polychemotherapy and its relationship with neurotoxicity were assessed using a model system of mononuclear leukocytes. Circulating EVs were isolated from 8 colorectal cancer patients who received antitumor therapy according to the FOLFOX or XELOX regimens before the start of chemotherapy (point 1) and after 3-4 courses (point 2).

[Phylogeography of pacific herring Clupea pallasii from Eurasian seas].

Eleven samples of Pacific herring from the four seas of Eurasia (Sea of Japan, Sea of Okhotsk, Bering Sea, and White Sea), and one sample of Atlantic herring were analyzed. Complete and partial sequences of the mtDNA control region with the sizes up to 1071 bp were used. To verify the haplogroups identified, additional sequencing of the cytochrome oxidase I gene was performed.