Publications by authors named "P N Nikolov"
Article Synopsis
- * The study included 226 patients with a mean age of 70.9 years, finding that DOAC treatment correlated with significantly lower all-cause and cardiovascular mortality compared to VKA treatment over a median follow-up of about 55 months.
- * VKA therapy was identified as an independent predictor of cardiovascular death, highlighting the advantages of using DOACs in patients with AF and coronary bifurcation lesions.
Objectives: Target localization for deep brain stimulation (DBS) is a crucial step that influences the clinical benefit of the DBS procedure together with the reduction of side effects. In this work, we address the feasibility of DBS target localization in the globus pallidus internus (GPi) aided by intraoperative motor evoked potentials (MEP) with emphasis on the reduction of capsular side effects.
Material And Methods: Micro-macroelectrode recordings were performed intraoperatively on 20 patients that underwent DBS treatment of the GPi (GPi-DBS).
Background: This preliminary retrospective cohort study investigates the potential additive prophylactic effect of erenumab, a fully human monoclonal antibody that blocks the calcitonin gene-related peptide receptor, in combination with ongoing onabotulinumtoxin A (onaBoNT-A) treatment in patients suffering from chronic migraine.
Methods: The study included 218 patients and investigated the effects of adding erenumab to the existing treatment regimen. The primary outcome was the MIDAS (Migraine Disability Assessment) score assessed 3 months after the introduction of erenumab.
Article Synopsis
- Side branch predilatation (SBPD) during coronary bifurcation interventions is discouraged by current guidelines, yet there is limited data on its long-term clinical outcomes.
- This study examined the long-term mortality outcomes for patients undergoing SBPD versus those who did not, using a large patient registry and careful statistical matching.
- Results showed that patients who underwent SBPD had higher all-cause and cardiovascular mortality rates compared to those who did not, indicating that while SBPD might improve angiographic results, it does not lead to better overall survival.
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) of still unclear etiology. In recent years, the search for biomarkers facilitating its diagnosis, prognosis, therapy response, and other parameters has gained increasing attention. In this regard, in a previous meta-analysis comprising 22 studies, we found that MS is associated with higher nitrite/nitrate (NOx) levels in the cerebrospinal fluid (CSF) compared to patients with non-inflammatory other neurological diseases (NIOND).
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