Publications by authors named "P N Manoj"
Riociguat is a soluble guanylate cyclase (sGC) activator that increases the levels of cyclic guanosine monophosphate (cGMP). cGMP is known to play a key role in regulating kidney function. This research sought to investigate the possible protective effects of riociguat on the kidneys in the context of chronic kidney disease (CKD).
View Article and Find Full Text PDFIntroduction Night eating syndrome (NES) is categorized as an eating disorder characterized by a delayed circadian rhythm of food intake and involves evening hyperphagia and/or nighttime awakening and food consumption two or more times per week. Young adults showed a higher prevalence of night eating, and students who reported high stress, irregular sleep patterns, and disordered eating may be more likely to develop NES symptoms. Objective This study aimed to assess the prevalence of Night Eating Syndrome among college students in Chengalpattu district of Tamil Nadu (India) and to find out the association between NES and socio-demographic variables and depression among the students.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on synthesizing a series of 4,6-diarylpyrimidin-2-amine derivatives that exhibit adjustable optical properties depending on the aryl groups attached to them, both in solid and solution states.
- - The synthesized compounds showed significant variability in their optical characteristics, including absorption and emission rates, with quantum yields ranging from 8.11% to 71.00% in DMF and specific fluorescence lifetimes.
- - The results suggest that these derivatives have potential applications in optoelectronics due to their unique dual-state emission properties and the ability to modify energy levels through different substituents.
This study aimed to investigate the potential protective effects of riociguat, a soluble guanylyl cyclase (sGC) stimulator, on kidney function and structure in rats with acute kidney injury (AKI) induced by the chemotherapeutic drug doxorubicin (DX). Rats were subjected to a single intraperitoneal injection of DX (13.5 mg/kg) on the 5th day, either alone or in combination with low-dose riociguat (3 mg/kg/day), or high-dose riociguat (10 mg/kg/day) for 8 consecutive days.
View Article and Find Full Text PDFObjectives: The purpose of this study was to assess, in a tertiary care context, the significance of C-reactive protein (CRP) in salivary gland illness.
Methods: This prospective research included 100 consecutive individuals with symptoms indicative of illness of the salivary glands. Demographic information, clinical information, and presenting symptoms were noted.