Sudden unexplained death in the young: epidemiology, aetiology and value of the clinically guided genetic screening.

Aims: To determine the incidence and the causes of sudden death (SD) in persons aged 1-35 years old and the diagnostic yield of clinically guided genetic screening in the sudden arrhythmic death syndrome (SADS) victims' families.

Methods And Results: Incidence and causes of SD in the Attica region of Greece in 2002-10 were determined using death certificates and autopsy reports. We evaluated clinically consecutive families of SADS victims and if a clinical diagnosis was established, we proceeded to targeted genetic analysis.

Histological findings of the atrioventricular conductive system in street heroin addicts, victims of sudden unexpected death.

A study of the atrioventricular (AV) conducting tissue was considered necessary for the examination of probable histologic changes that could justify the arrhythmias observed in street-heroin addicts. Postmortem coronary angiography and microscopic examination were performed in 50 heroin addicts (group A) and in 50 nonaddicts (group B), all male 16-40 years old. In group A, fatty and/or fibrous tissue replaced the AV node in 50% of cases while in group B in 14%.

Histologic findings of the sinus node and the perinodal area in street heroin addicts, victims of sudden unexpected death.

Sudden unexpected death is frequent in street heroin addicts. We conducted a histologic study of the sinus node (SN) to offer some evidence about the possible arrhythmogenic cause of death. Postmortem coronary angiography and microscopic examination of the SN and the perinodal area were performed in 50 heroin addicts (group 1) and in 50 nonaddicts (group 2), all men (16-40 years old).

Variation in the blood supply of the sinus node.

Purpose: The purpose of the study was to examine the anatomical variations in the blood supply to the sinus node.

Methods: Gross anatomical examination and angiographic evaluation were performed in 400 human hearts derived from victims of various accidents.

Results: The sinus node artery was a branch of the right coronary artery in 245 cases, the left circumflex in 147 cases, and both coronary arteries in 8 cases.

A secret pathway of the sinus node artery.

Anatomic and postmortem angiographic findings of a previously unreported case of common origin of the left circumflex (LCX) and the sinus node (SN) arteries, from the left main (LM) coronary artery were demonstrated. Knowledge of this anatomical variation, although it does not give rise to symptoms, is essential for anatomist and mainly for the interventional cardiologists and cardiac surgeons for their procedures.