[Immunity to tumors induced by herpes simplex virus in hamsters].

Preparations of early herpes simplex virus antigen (VIA) and specific antibodies to it were used to induce active and passive immunity to herpes virus-induced tumors in experimental animals. The results demonstrated the increased resistance of animals to transplantation of tumor cells due to vaccination with VIA-containing preparations. Thus, in VIA-vaccinated animals there was a delay in the development of tumors and the survival time was significantly higher than in the controls.

[Protective action of cytotoxic lymphocytes depending on the antigenic determinant composition of influenza virus hemagglutinin].

The protective role of cytotoxic lymphocytes (CTL) in dependence on composition of antigenic determinants of hemagglutinin of influenza viruses H3N2 was studied. It was established that CTL do not exert protective effect under conditions of adoptive transfer, when there is one common antigenic determinant in hemagglutinins of the virus forming immunity. When all antigenic determinants in hemagglutinins of influenza viruses are identical, CTL-like antibodies represent one of the main factors of antivirus immunity.

[Antigenic-genetic connections between human and animal influenza viruses].

A comparative immunological analysis of the composition of antigenic determinants (AGD) in hemagglutinins of human influenza A virus (HIAV) of the serosubtypes H1, H2, H3, and in hemagglutinins of animal influenza viruses (AIV) of the serosubtypes H1, H3-H6, H8-H11 with 25 polyclonal highly active sera was demonstrated. Using original monospecific mon AGD in HIAV and AIV hemagglutinins was demonstrated. Using original monospecific antibodies to individual AGD, those AGD contributing to similarity and differences between HIAV and AIV were determined.

[Thomsen's antigen in the leukocytes of leukemia patients].

Leukocytes of 19 leukemic patients and 10 healthy donors were tested for the presence of Thomsen's antigen, using a method of specific adsorption of isogenic sera. Before the adsorption the cells were sonicated. Thomsen's antigen was found in leukocytes of leukemic patients but not in cells of healthy donors.

[Herpes simplex virus-associated antigen in leukemic cells].

Immunological methods (CFT, indirect IF) detected herpes simplex virus-associated antigen in leukocytes of 21 out of 56 leukemia patients. The antigen was more frequently found in leukocytes of patients with chronic lympho- and myeloleukemias, less frequently in acute forms of these diseases. No antigen was detectable in leukocytes of normal donors.