Publications by authors named "P N Izzo"

Article Synopsis
  • Varicose veins should be understood as part of the larger issue of chronic venous insufficiency (CVI), prompting the MEVeC project to enhance assessment methods and standardize treatment evaluations across practitioners.
  • The study evaluated surgical vs. laser treatment in patients with specific varicose vein conditions, using ultrasound Doppler to examine outcomes after interventions.
  • Results showed lower reflux rates in the surgical group compared to the laser group, highlighting the need for ongoing standardization and understanding of treatment efficacy in managing CVI.
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Aim: Primary hepatic neuroendocrine carcinomas (PHNECs) are rare tumors with limited understanding and management. Diagnosing and treating these tumors pose significant challenges due to the lack of clinical experience. Surgery is often considered an effective therapeutic strategy for early-stage PHNECs.

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Background: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary kidney disorder that may progress to kidney failure, accounting for 5-10% of all patients with end-stage kidney disease (ESKD). Clinical data, as well as molecular genetics and advanced imaging techniques have provided surrogate prognostic biomarkers to predict rapid decline in kidney function, nonetheless enhanced tools for assessing prognosis for ADPKD are still needed. The aim of this study was to analyze specific microRNAs involved in the pathogenesis of ADPKD and in the development of renal fibrosis, evaluating their potential role as predictors of renal function loss.

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Article Synopsis
  • The COVID-19 pandemic highlighted the effects of viral infections on individuals with existing kidney conditions like Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Chronic Kidney Disease (CKD).
  • This study analyzed data from 103 patients to assess changes in renal function before and one year post-COVID-19 infection, focusing on ADPKD and CKD patients.
  • Results indicated that ADPKD patients experienced significantly worse renal function post-infection compared to CKD patients, particularly those with lower estimated glomerular filtration rates (eGFR), pointing to a complex relationship between COVID-19 and kidney disease.
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Radiomics represents the convergence of artificial intelligence and radiological data analysis, primarily applied in the diagnosis and treatment of cancer. In the head and neck region, squamous cell carcinoma is the most prevalent type of tumor. Recent radiomics research has revealed that specific bio-imaging characteristics correlate with various molecular features of Head and Neck Squamous Cell Carcinoma (HNSCC), particularly Human Papillomavirus (HPV).

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