Publications by authors named "P N GARCEZ"
Article Synopsis
- Pelvic pain, located below the umbilical scar, often requires additional treatments like electric stimulation due to the limitations and side effects of pharmacological therapy.
- A comprehensive literature review up to April 2024 evaluated the effectiveness of various electrostimulation methods for pelvic pain, assessing risk of bias and evidence quality through established tools.
- Findings revealed that while various electrical stimulation methods showed some promise, only Transcutaneous Electrical Nerve Stimulation (TENS) demonstrated significant effectiveness for reducing acute pelvic pain and primary dysmenorrhea, indicating a need for more rigorous studies on other techniques.
Prenatal Exposure to Herbicide 2,4-Dichlorophenoxyacetic Acid (2,4D) Exacerbates Zika Virus Neurotoxicity In Vitro and In Vivo.
Environ Toxicol
February 2025
Article Synopsis
- - The Zika virus can cause Congenital ZIKV syndrome (CZS) during pregnancy, leading to malformations like microcephaly, with varying prevalence across Brazil, particularly in the Northeast and Central-West regions.
- - A study found that exposure to the agrochemical 2,4-dichlorophenoxyacetic acid (2,4D), commonly used in Brazil, worsens the neurotoxic effects of ZIKV in human cells and mice models, resulting in smaller brain size and increased cell death.
- - There is a notable correlation between the prevalence of CZS and the use of 2,4D in certain Brazilian regions, suggesting that this agrochemical may enhance the transmission of Z
Congenital zika virus syndrome (CZS) has become a significant worldwide concern since the sudden rise of microcephaly related to zika virus (ZIKV) in Brazil. Primarily transmitted by Aedes mosquitoes, ZIKV shares serologic similarities with dengue virus (DENV), complicating the diagnosis and/or clinical management. The Angiotensin I-Converting Enzyme (ACE) was associated with either neuroprotective or anti-inflammatory properties in the central nervous system (CNS).
View Article and Find Full Text PDFThe Zika virus received significant attention in 2016, following a declaration by the World Health Organization of an epidemic in the Americas, in which infections were associated with microcephaly. Indeed, prenatal Zika virus infection is detrimental to fetal neural stem cells and can cause premature cell loss and neurodevelopmental abnormalities in newborn infants, collectively described as congenital Zika syndrome. Contrastingly, much less is known about how neonatal infection affects the development of the newborn nervous system.
View Article and Find Full Text PDF