[Niemann-Pick disease type C in monozygotic twins].

The Authors describe two monochorionic twins affected by Niemann-Pick disease type C with a clinical picture beginning in the neonatal age and with a progressive mental deterioration, loss of speech and spasticity started at 30 months. The importance of cultured skin fibroblasts is emphasized. The evidence of a defective intracellular cholesterol esterification is established as an intrinsic feature of Niemann-Pick disease type C.

[Growth, thyroid function, pubertal development and gonadal function in survivors of childhood brain tumors].

The aggressive use of multiple therapeutic modalities has led to a significant increase in the number of survivors of childhood malignancy. Abnormalities of linear growth, thyroid function and sexual development are encountered often in children and adolescents following the successful treatment of brain tumours.

[Long-term results (May 1989-May 1990) concerning the mandatory use of restraining systems --safety belt and car chair-- for children in Italy].

Results of one year follow-up of children restraint system mandatory use in Italy are exposed: transgression are not pursued and a frequent traumatical pathology for the childhood takes place.

[The safe transportation of children in automobiles].

The Author emphasizes the significant number of children who sustain fatal accidents during their transport on motor vehicles and relates the Act recently promulgated by the Italian Parliament on the mandatory use of particular restraining devices as well as safety harness for children.