Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction.

The GH secretagogue receptor (GHSR) and the glucagon-like peptide-1 receptor (GLP-1R) are G protein-coupled receptors with critical, yet opposite, roles in regulating energy balance. Interestingly, these receptors are expressed in overlapping brain regions. However, the extent to which they target the same neurons and engage in molecular crosstalk remains unclear.

Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain.

The growth hormone secretagogue receptor (GHSR) and the cannabinoid receptor type 1 (CB1R) are G-protein coupled receptors highly expressed in the brain and involved in critical regulatory processes, such as energy homeostasis, appetite control, reward, and stress responses. GHSR mediates the effects of both ghrelin and liver-expressed antimicrobial peptide 2, while CB1R is targeted by cannabinoids. Strikingly, both receptors mediate their effects by acting on common brain areas and their individual roles have been well characterized.

Training and Support Needs in Transitional Care From Hospital to Home of the Health Care Professional-Caregiver-Stroke Survivor Triad: A Meta-Synthesis Study.

Introduction: Stroke represents the second leading cause of death worldwide after cardiovascular disease and the first cause of disability in adults. Only 25% of stroke survivors fully recover, 75% survive with some form of disability, and half of them lose self-sufficiency, negatively impacting their quality of life. This study aims to understand the experiences of stroke survivors and caregivers of training needs and support during the transitional care phase from hospital to home; it also investigates the experience of health care professionals (HCPs) of providing support and training to the dyad during this phase.

Ruijsenaars wavefunctions as modular group matrix coefficients.

We give a description of the Hallnäs-Ruijsenaars eigenfunctions of the 2-particle hyperbolic Ruijsenaars system as matrix coefficients for the order 4 element acting on the Hilbert space of (2) quantum Teichmüller theory on the punctured torus. The (2) Macdonald polynomials are then obtained as special values of the analytic continuation of these matrix coefficients. The main tool used in the proof is the cluster structure on the moduli space of framed (2)-local systems on the punctured torus, and an -equivariant embedding of the (2) spherical DAHA into the quantized coordinate ring of the corresponding cluster Poisson variety.