Publications by authors named "P N Bhattacharyya"
Article Synopsis
- This study explores how bauxite mining impacts soil quality and microbial health in mining-adjacent areas, which has been under-researched compared to other types of mining like coal and copper.
- Soil samples from locations near an active bauxite mine showed high levels of heavy metals (like chromium and lead), acidity, and aluminum, negatively affecting important microbial indicators such as enzyme activity and microbial biomass.
- The research found that the concentrations of organic carbon could help mitigate some of the acidity effects, with acid phosphatase enzyme being a key factor in differences seen across various sampling sites.
Background/objectives: Those with the genetic disorder Down syndrome are at high risk of developing Alzheimer's disease. Previous work shows group differences in magnetic resonance spectroscopy metabolite measures in adults with Down syndrome who have Alzheimer's disease-related dementia compared to those who do not. In this pilot study, we assess relationships between metabolites and measures related to dementia status in a sample of adults with Down syndrome.
View Article and Find Full Text PDFBackground & objectives Spirometric glycopyrronium responsiveness, a new advent, needs to be examined at in terms of degree and frequency in different obstructive-airway diseases diagnosed in real world practise. Methods Serial and willing symptomatic affected individuals of suspected airway disease underwent a pragmatic post-consultation spirometry-protocol on the same day with salbutamol followed by glycopyrronium bromide. The diagnosis of asthma (FEV1-reversibility ≥ 200 ml + 12%), chronic obstructive pulmonary disease (COPD) (FEV1/FVC<0.
View Article and Find Full Text PDFCellular mechanical dysregulation can lead to diseases and conditions like tumorigenesis. Drug delivery systems that recognize and respond to specific cellular mechanical characteristics are potentially useful for targeted therapy. We report here the creation of a DNA mechanical nanovehicle that is responsive to cell surface receptor-mediated tensile forces, which can then correspondingly deliver an anticancer drug in situ.
View Article and Find Full Text PDFArticle Synopsis
- Cell-generated forces play a crucial role in various cellular processes, and measuring these forces is essential for understanding cell behavior in contexts like migration and cancer development, although existing methods are often complex and require specialized skills.
- A new smartphone-based electrochemical sensor has been developed, utilizing a DNA-based force probe that can detect cellular forces, enabling the measurement of small forces generated by just a few cells, like HeLa cells, through enhanced electrochemical signals.
- This innovative sensor is portable, cost-effective, and user-friendly, making it a promising complementary tool to existing techniques for detecting cellular forces in biological research.