Publications by authors named "P Myhre"
Predictors of coronary atherosclerosis in middle-aged and older athletes: the MARC-2 study.
Eur Heart J Cardiovasc Imaging
December 2024
Aims: Exercise improves cardiovascular health, but high-volume high-intensity exercise is associated with increased coronary artery atherosclerosis and calcification (CAC). We aimed to identify predictors of CAC in athletes.
Methods And Results: We assessed the association of traditional and non-traditional cardiovascular risk factors with CAC using linear and logistic regression.
Article Synopsis
- N-terminal pro-B-type natriuretic peptides (NT-proBNPs) are important biomarkers for evaluating heart failure risk, but their levels can be misleading in patients with chronic kidney disease due to the kidney’s impact on eGFR.
- This study aimed to analyze the relationship between NT-proBNP levels and cardiovascular outcomes, specifically hospitalizations and deaths, in heart failure patients with varying kidney function.
- In a large cohort of over 14,000 patients, the results indicated that NT-proBNP levels significantly increased with lower eGFR levels, and every doubling of NT-proBNP was linked to a 37% higher risk of adverse cardiovascular outcomes.
Background: Higher circulating concentrations of NT-proBNP (N-terminal pro-B-type natriuretic peptide) and high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-cTnI) are associated with left ventricular remodeling and with incident heart failure. The associations of these cardiac biomarkers with changes in cardiac structure and function over time are uncharacterized.
Methods: Among 2006 participants in the ARIC prospective cohort study (Atherosclerosis Risk in Communities) who were free of overt cardiovascular disease and underwent echocardiography at study visits 5 (2011- 2013) and 7 (2018-2019), we assessed the associations of NT-proBNP, hs-cTnT, and hs-cTnI concentrations at visit 5 with changes in left ventricular structure and function between visits 5 and 7 (≈7-year change) using multivariable linear regression with the biomarkers modeled as restricted cubic splines.
Article Synopsis
- * The rise of technology and global connectivity supports the use of these tools, yet challenges persist in treatment effectiveness, especially in lower-income regions.
- * To maximize the benefits of digital health tools, it's essential to create supportive systems and clinical frameworks that can be applied worldwide.