Publications by authors named "P Mortini"
TSH-secreting pituitary adenoma (TSHoma) is the rarest functioning pituitary tumor, with an increasing incidence over the last decades. Diagnosis is often delayed, exposing patients to a high risk of developing chronic complications of long-standing hyperthyroidism. Although thyroid hormone excess is a recognized cause of secondary osteoporosis, very few studies have investigated skeletal damage in patients with TSHoma, with data limited to bone turnover markers (BTM) and a study on the prevalence of radiological vertebral fractures (VFs) incidentally detected on chest X-ray, whereas data on bone mineral density (BMD) are anecdotal.
View Article and Find Full Text PDFGlioblastoma (GBM) is the most common, fast-growing, and aggressive malignant primary CNS tumor, with a survival time of ~15 months despite the use of surgery and adjuvant treatments. In recent years, there has been a growing interest in exploring the potential contribution of hemostasis and platelet activation in GBM biology. The present study assessed the association between the pre-operative coagulation profile [as indicated by prothrombin time (PT) ratio and activated partial thromboplastin time (aPTT) ratio], overall platelets (PLT) count and the mean platelet volume (MPV) with tumoral characteristics and overall survival in patients with isocitrate dehydrogenase-wildtype (IDH-wt) GBM.
View Article and Find Full Text PDFHow safe and effective is irradiating radiation-induced meningiomas? Single-center experience in primary and salvage Gamma-Knife Radiosurgery, systematic review, and metanalysis of current evidence on the topic.
Crit Rev Oncol Hematol
December 2024
Article Synopsis
- This study looked at the safety and effectiveness of a treatment called Gamma-knife stereotactic radiosurgery (SRS-GK) for a type of brain tumor called radiation-induced meningiomas (RIMs) at a hospital in Italy.
- They included data from 13 patients and found that 26% improved, while 52% stayed the same and 22% got worse, with a good control rate over 5 years.
- In a bigger analysis, including 146 patients, the overall success rate was high, but some patients experienced side effects like swelling, showing that while SRS-GK works well, there can be risks involved.
Metastatic spread to the central nervous system (CNS) is frequent in anaplastic lymphoma kinase ( ALK )-rearranged non-small cell lung cancer (NSCLC) and has an important impact on patient prognosis and quality of life. Leptomeningeal involvement may occur in up to 10% of cases of ALK-positive NSCLC. Lorlatinib is a third-generation ALK inhibitor that has excellent CNS penetrability and demonstrated its efficacy both in pretreated and treatment-naive patients.
View Article and Find Full Text PDFContext: a paradoxical growth hormone (GH) response to oral glucose load (OGTT) in acromegaly is associated with a milder phenotype.
Objective: To study whether the GH response to OGTT predicts the risk of recurrence after initial surgical cure.
Design: Retrospective, observational study.