Publications by authors named "P Morselli"
Article Synopsis
- Type-2 Familial Partial Lipodystrophy (FPLD2) leads to fat loss in the trunk and limbs while causing excess fat deposits in the neck and face, linked to mutations affecting adipose tissue function.* -
- Research indicates that the mineralocorticoid receptor (MR) is crucial in the differentiation of adipose tissue, with FPLD2 affecting the MR's location within cells, resulting in abnormal fat cell development.* -
- Treatment with the MR antagonist spironolactone has shown promise in redirecting FPLD2 preadipocyte differentiation toward a healthier 'brown' fat type, which can improve fat tissue function in affected patients.*
The demand for masculinizing breast surgery and hysterectomy with bilateral salpingo-oophorectomy (HBSO) from transmen has increased. With a multidisciplinary approach, these surgeries can be performed in a single session. The objective of this study was to retrospectively evaluate the feasibility, safety, and satisfaction of HBSO and chest surgery in transmen.
View Article and Find Full Text PDFClosure of a tracheoesophageal puncture site performed during voice prosthesis implantation may sometimes be required. Besides local techniques, more elaborate procedures, such as closure by means of free microvascular flaps, have been advocated. In this report, we describe a case of local treatment of a hard-to-heal fistula with local application of autologous platelet-rich fibrin matrix in a 77-year-old male patient.
View Article and Find Full Text PDFA Randomized Double-Blind Placebo-Controlled Pilot Trial on the Effects of Testosterone Undecanoate Plus Dutasteride or Placebo on Muscle Strength, Body Composition, and Metabolic Profile in Transmen.
J Sex Med
March 2021
Background: While the effects of androgens on muscle are well described in hypogonadal men, literature is still scarce on muscular strength or size variations in transmen; in this population there are no data regarding the relative effect of testosterone (T) and its metabolite dihydrotestosterone on muscle.
Aim: Our primary objective was to compare the effects on muscle strength of 54-week administration of testosterone undecanoate (TU) combined with the 5α-reductase inhibitor dutasteride (DT) or placebo (PL). Secondary outcomes included evaluation of body composition, bone, cutaneous androgenic effects, and metabolic variations.
Purpose: The aim of this study was to evaluate the effects exerted over chondrogenic commitment of human adipose-derived mesenchymal stem cells (ADSCs) by a very low oxygen tension (<1% pO).
Materials/methods: Cell morphology, mRNA levels of chondrocyte-specific marker genes and the involvement of p38 MAPK signalling were monitored in human ADSCs under a very low oxygen tension.
Results: Cell morphology was significantly changed after two days of hypoxic preconditioning when they featured as elongated spindle-shaped cells.