Publications by authors named "P Moreno-Acosta"
Article Synopsis
- - Emerging countries are experiencing a rising cancer burden but lack sufficient prevention, monitoring, and research resources to manage it effectively.
- - Differences in cancer care between emerging and developed countries highlight the need for actions aimed at achieving global health equity.
- - Establishing cooperative programs in the oncology field, focusing on research, training, and evidence-based practices, can help tackle the global cancer burden.
Human papillomavirus (HPV) infection is strongly associated with cervical cancer (CC). Genomic alterations caused by viral infection and subsequent dysregulation of cellular metabolism under hypoxic conditions could influence the response to treatment. We studied a possible influence of IGF-1Rb, hTERT, HIF1a, GLUT1 protein expression, HPV species presence and relevant clinical parameters on the response to treatment.
View Article and Find Full Text PDFSince radiotherapy discovery, prediction of biological response to ionizing radiation remains a major challenge. Indeed, several radiobiological models appeared through radiotherapy history. Nominal single dose so popular in the 1970s, was tragically linked to the dark years in radiobiology by underestimating the late toxicity of the high-dose fractions.
View Article and Find Full Text PDFScarce data investigate the impact of radiotherapy (RT) on biology markers. An analysis of ancillary study of RIT (Radiation Impact on Thromboembolic events) prospective trial was carried out. All patients with non-metastatic solid tumors and treated with radiotherapy and/or brachytherapy in curative and consenting to have blood samples were included.
View Article and Find Full Text PDFBackground/aim: Although some mutations of KRAS proto-oncogene, GTPase (KRAS) have been associated with the prognosis and therapeutic management of colorectal cancer (CRC), the epigenetic mechanisms (DNA methylation and microRNA expression) that regulate wild-type KRAS expression in patients with CRC are poorly known. The aim of this study was to establish whether there is a relationship between the expression of the wild-type KRAS gene, the methylation status of its distal promoter, and miR-143 and miR-18a-3p levels in samples of sporadic CRC.
Patients And Methods: A total of 51 cases of sporadic CRC with wild-type KRAS were analyzed.