Publications by authors named "P Mordant"
Background: Incidental lung cancer, in the field of lung transplantation (LTx), is more often related to malignancies diagnosed in explants or transplanted organs. Little is known about cancer diagnosed during the medical evaluation of potential LTx candidates. What are the clinical, and prognostic differences between lung cancers diagnosed before or after transplantation in LTx candidates?
Methods: We performed a retrospective, observational, single-center study to describe the characteristics of lung malignancies first discovered during the pre-transplant assessment and then identified in lung explants, over the same period.
FGF21 Signaling Exerts Anti-Fibrotic Properties During Pulmonary Fibrosis.
Am J Respir Crit Care Med
December 2024
Rationale: Idiopathic Pulmonary Fibrosis (IPF) is a lethal disease with limited therapeutic options. FGF21, an endocrine fibroblast growth factor that acts through the FGFR1/KLB pathway, mitigates liver fibrosis.
Objectives: We hypothesized that FGF21 could exert anti-fibrotic properties in the lung.
Identification of FGFR4 as a regulator of myofibroblast differentiation in pulmonary fibrosis.
Am J Physiol Lung Cell Mol Physiol
December 2024
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with limited therapeutic options. Fibroblast growth factor receptor-4 (FGFR4) is a known receptor for several paracrine fibroblast growth factors (FGFs). FGFR4 is also the main receptor for FGF19, an endocrine FGF that was demonstrated by our group to have antifibrotic properties in the lung.
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- The study examines lung transplantation (LT) outcomes in patients aged 65 and older compared to younger recipients, emphasizing that age shouldn't be a strict barrier for the procedure.
- Researchers conducted a retrospective analysis of patients who underwent LT at Bichat Hospital, tracking 90-day mortality and other long-term health markers.
- Results showed that while elderly patients had better short-term lung function post-transplant, their overall survival rates and mortality within the first year were similar to those of younger patients.
Article Synopsis
- * Researchers studied robot-assisted surgery (RAS) in a French hospital to see if it helped patients leave the hospital sooner compared to traditional surgeries.
- * They found that RAS led to shorter hospital stays, especially for urology patients, saving a lot of hospital days and helping hospitals take care of more patients.