Publications by authors named "P Monaghan"
: Persons with multiple sclerosis (MS) experience changes in balance, such as poor and reactive stepping, as well as altered fall-related psychological factors, such as increased concern about falling and feared consequences about falling. Such concerns and fear may relate to and influence mobility. However, these relations are poorly understood in people with MS.
View Article and Find Full Text PDFOffspring of older breeders frequently show reduced longevity, which has been linked to shorter offspring telomere length. It is currently unknown whether such telomere reduction persists beyond a single generation, as would be the case if germline transmission is involved. In a within-grandmother, multi-generational study using zebra finches, we show that the shorter telomeres observed in F1 offspring of older mothers are still present in the F2 generation even when the breeding age of their F1 mothers is young.
View Article and Find Full Text PDFIntroduction: Breast cancer is the most common malignancy worldwide. The disease is more severe in younger women and often confers a poorer prognosis. This study aimed to profile a cohort of young women with breast cancer and address whether aspects of their tumour biology were related to their long-term outcomes.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how proprioception affects backward walking (BW) compared to forward walking (FW) in people with multiple sclerosis (MS), noting that MS patients have slowed sensory conduction, increasing their fall risk.
- - Fifty participants were tested for proprioception using vibration sensation as a measure while walking both backward and forward at different speeds, with findings highlighting a stronger link between proprioceptive abilities and BW.
- - Results show fallers (MS individuals who have experienced falls) had worse proprioception than non-fallers, emphasizing the need for targeted fall risk assessments and interventions that focus on improving proprioception, particularly in the context of BW.
Background: Anti-angiogenic, VEGF inhibitors (VEGFi) increase progression-free survival (PFS) and, in some cases, overall survival in many solid tumours. However, their use has been compromised by a lack of informative biomarkers. We have shown that plasma Tie2 is the first tumour vascular response biomarker for VEGFi in ovarian, colorectal and gall bladder cancer: If plasma Tie2 concentrations do not change after 9 weeks of treatment with a VEGFi, the patient does not benefit, whereas a confirmed reduction of at least 10% plasma Tie2 defines a vascular response with a hazard ratio (HR) for PFS of 0.
View Article and Find Full Text PDF