Publications by authors named "P Moliner"
Previous studies showed that, paradoxically, obese patients with heart failure (HF) have better clinical outcomes compared to overweight, normal, or underweight patients. Scientific societies emphasize the importance of integrating quality of life (QoL) assessment in cardiovascular care. However, the association between QoL and weight remains understudied.
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- Biotransformation is a crucial area within drug metabolism and pharmacokinetics that evaluates metabolites to ensure drug safety and compliance with regulatory guidelines.
- Metabolite identification (metID) scientists use various strategies to identify human metabolites early in drug development and assess exposure risks, following guidelines like the Metabolites in Safety Testing (MIST).
- A survey involving 26 pharmaceutical companies aimed to evaluate the effectiveness of current in vitro metID practices in predicting human metabolites, highlighting the need for a standardized framework and looking toward future advancements.
Pericardial disease is increasingly recognized in cancer patients, including acute pericarditis, pericardial effusion, and constrictive pericarditis, often indicating a poor prognosis. Acute pericarditis arises from direct tumor involvement, cancer therapies, and radiotherapy. Immune checkpoint inhibitor (ICI)-related pericarditis, though rare, entails significant mortality risk.
View Article and Find Full Text PDFBackground And Aims: Baseline cardiovascular toxicity risk stratification is critical in cardio-oncology. The Heart Failure Association (HFA) and International Cardio-Oncology Society (ICOS) score aims to assess this risk but lacks real-life validation. This study validates the HFA-ICOS score for anthracycline-induced cardiovascular toxicity.
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