Publications by authors named "P Moles-Poveda"
Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most efficient therapeutic options available to cure many hematological malignancies. However, severe complications derived from this procedure, including graft-versus-host disease (GVHD) and infections, can limit its success and negatively impact survival. Previous studies have shown that alterations in the microbiome are associated with the development of allo-HSCT-derived complications.
View Article and Find Full Text PDFTreatment of steroid-refractory chronic graft-versus-host disease (cGVHD) is a challenge. Here, we describe a retrospective analysis of 66 patients with steroid-refractory cGVHD treated with imatinib (starting dose of 100 mg in 70% of patients; maximum dose of 100-200 mg in 74%). Most patients had multi-organ involvement (≥2 organs, 83%), with the most affected being skin (85%), oral mucosa (55%), eyes (42%), and lungs (33%).
View Article and Find Full Text PDFArticle Synopsis
- Graft-versus-host disease (GVHD) affects a significant percentage of patients after allogeneic stem cell transplants, with sclerotic features impacting 10%-15% of these individuals, leading to diminished quality of life and functional limitations.
- There is a lack of research on effective rehabilitation methods for sclerotic GVHD (sclGVHD), prompting a review of existing evidence and proposed multidisciplinary management strategies in this article.
- The authors also discuss various techniques used for other sclerotic skin conditions that could potentially benefit sclGVHD patients, highlighting the need for tailored rehabilitation programs to optimize care.
Trichomegaly is a known adverse effect of systemic administration of cyclosporine but is less commonly associated with systemic tacrolimus or with topical calcineruin inhibitors. In this report, we describe the first case, to our knowledge, of trichomegaly due to long-term use of topical tacrolimus for periocular vitiligo.
View Article and Find Full Text PDFTelomerase Expression in a Series of Melanocytic Neoplasms.
Actas Dermosifiliogr (Engl Ed)
April 2019
Background And Objectives: Telomerase is an enzyme involved in maintaining the length of telomeres and cell senescence. Numerous studies have shown that in more than 90% of malignant tumors telomerase activity is detected.
Material And Methods: Retrospective observational study in a series of 85 cases of primary melanomas, 12 metastatic melanomas, and 22 melanocytic nevi.