Publications by authors named "P Mohankrishna"
Aims And Hypothesis: India has the greatest number of diabetic subjects in any one country, but the genetic basis of type 2 diabetes mellitus in India is poorly understood. Common non-coding variants in the transcription factor 7-like 2 gene (TCF7L2) have recently been strongly associated with increased risk of type 2 diabetes in European populations. We investigated whether TCF7L2 variants are also associated with type 2 diabetes mellitus in the Indian population.
View Article and Find Full Text PDFBackground: The APOA5 gene variants, -1131T>C and S19W, are associated with altered triglyceride concentrations in studies of subjects of Caucasian and East Asian descent. There are few studies of these variants in South Asians. We investigated whether the two APOA5 variants also show similar association with various lipid parameters in Indian population as in the UK white subjects.
View Article and Find Full Text PDFArticle Synopsis
- Peutz-Jeghers syndrome (PJS) is a rare cancer syndrome linked to mutations in the STK11 gene; however, not all cases can be explained by these mutations, leading to exploration of other genetic factors.
- In this study, researchers sequenced the STK11 gene in 16 individuals from ten Indian families and found a novel mutation in only one patient, suggesting the complexity of PJS genetics.
- The findings indicate that while STK11 mutations can be present in some cases, there likely exists other genetic factors or larger genomic changes contributing to PJS among Indian patients that require more research.