Publications by authors named "P Miron"
To identify novel genes responsible for recurrent hydatidiform moles (HMs), we performed exome sequencing on 75 unrelated patients who were negative for mutations in the known genes. We identified biallelic deleterious variants in 6 genes, FOXL2, MAJIN, KASH5, SYCP2, MEIOB, and HFM1, in patients with androgenetic HMs, including a familial case of 3 affected members. Five of these genes are essential for meiosis I, and their deficiencies lead to premature ovarian insufficiency.
View Article and Find Full Text PDFImpact of universal use of the McGrath videolaryngoscope as the first option for all intubations in the operating room: The multicentre prospective before-after VIDEOLAR-SURGERY study protocol.
Rev Esp Anestesiol Reanim (Engl Ed)
November 2024
Article Synopsis
- The study aims to determine if the McGrath video laryngoscope, used as the first option for tracheal intubation, improves ease of intubation and reduces complications compared to the traditional Macintosh laryngoscope.
- It's conducted as a multicenter trial involving 35 anesthesiologists across several hospitals, tracking outcomes before and after implementation of the video laryngoscope.
- The study has ethical approval, requires informed consent from participants, and intends to publish its findings in a peer-reviewed journal and present at scientific conferences.
Article Synopsis
- There is a lack of consensus on the best videolaryngoscope for awake tracheal intubation in patients expected to have difficult airways, leading to a study comparing the C-MAC D-Blade® and Airtraq®.
- A randomized clinical trial involved 90 adult patients undergoing surgery with anticipated difficult airways, focusing on the first-attempt tracheal intubation success rate as the primary outcome.
- Results showed a significantly higher first-attempt success rate for the C-MAC D-Blade (84%) compared to the Airtraq (62%), while overall success rates were similar for both, suggesting the C-MAC D-Blade may be more effective for initial intubation attempts.
The computer-assisted program SiD was developed to assess and select sperm in real time based on motility characteristics. To date, there are limited studies examining the correlation between AI-assisted sperm selection and ICSI outcomes. To address this limit, a total of 646 sibling MII oocytes were randomly divided into two groups as follows: the ICSI group (n = 320): ICSI performed with sperm selected by the embryologist and the ICSI-SiD group (n = 326): ICSI performed with sperm selected using SiD software.
View Article and Find Full Text PDFInfertility affects around 20% of couples of reproductive age; however, in some societies, as many as one-third of couples are unable to conceive. Different factors contribute to the decline of male fertility, such us environmental and professional exposure to endocrine disruptors, oxidative stress, and life habits with the risk of de novo epigenetics dysregulation. Since the fantastic development of new "omes and omics" technologies, the contribution of inherited or de novo genomes and epigenome disorders to male infertility have been further elucidated.
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