Modulation of morphine antinociceptive and rewarding effect by mirtazapine in an animal model of osteoarthritic pain.

People with chronic pain mitigate their suffering by the action of opioids. Adverse reactions aside, opioids are not exempt from potential complications like addiction and abuse, which have posed a global public health problem lately. Finding new therapeutic strategies to improve analgesia and to reduce opioid side effects has become a priority.

Review of Pharmacological and Medicinal Uses of Punica granatum.

Pomegranates () are a fruit renowned for their rich history, diverse uses, and substantial health benefits. Current research on the botanical features, nutritional profile, and medicinal properties of pomegranates is summarized in this study. Botanically, the pomegranate is classified as a deciduous shrub with a unique fruit structure comprising numerous seeds, or arils, embedded in a leathery skin.

Efficient brain tumor grade classification using ensemble deep learning models.

Detecting brain tumors early on is critical for effective treatment and life-saving efforts. The analysis of the brain with MRI scans is fundamental to the diagnosis because it contains detailed structural views of the brain, which is vital in identifying any of its abnormalities. The other option of performing an invasive biopsy is very painful and uncomfortable, which is not the case with MRI as it is free from surgically invasive margins and pieces of equipment.

Physicochemical and biological evaluation of 'click' synthesized vinyl epoxide-chitosan film for active food packaging.

Chitosan (Cs) being a natural biopolymer serves as an excellent template to construct active packaging materials for achieving sustainable development. In this study, Cs was chemically modified via epoxide ring opening click reaction using vinyl epoxide to obtain a novel chitosan vinyl epoxide (Cs-VE) derivative with hydroxyl and olefinic functional groups. The Cs-VE transparent film was fabricated through the eco-friendly solution casting technique.

Novel PPAR-γ agonists as potential neuroprotective agents against Alzheimer's disease: rational design, synthesis evaluation, PPAR-γ binding assay and transactivation and expression studies.

Alzheimer's disease (AD) is a neurological disorder. It is caused by accumulation of amyloid beta (Aβ) plaques and tau tangles, which gradually leads to cognitive decline and memory loss. Peroxisome proliferator-activated receptor gamma (PPAR-γ), a nuclear receptor, plays a significant role in regulating genes responsible for metabolism and inflammation.