Effect of an antidiencephalon immune serum on pain and sleep in primary fibromyalgia.

The results of a double-blind, randomized, therapeutical trial with SER282, an antidiencephalon immune serum (Serolab, Lausanne, Switzerland), in 36 women, aged 24-56 years, with primary fibromyalgia are presented. Treatment was ambulatory and consisted of either SER282 (20 mg/ml) or amitryptiline (AMI, 50 mg) or placebo (PL) over an 8-week treatment course. Clinical and sleep EEG polygraphic data were obtained at baseline and after 4 and/or 8 weeks of therapy.

Anti-stomach serum induces contraction of isolated smooth muscle cells from gastric antrum.

In this work, we investigated the ability of anti-tissue sera to cause contraction of smooth muscle cells (SMC) in vitro. Therefore, we compared the effects of a horse immune serum raised against hog gastric tissue (SER 292), of its globulin fraction (SER 292 globulin), and of its IgG fraction (SER 292 IgG), on concentration of isolated SMC from the gastric antrum of the rabbit. Our results showed that SER 292 IgG induced a dose-dependent contraction of SMC with a higher potency than SER 292 globulin and SER 292.

[Effects of anti-tissue immune sera on the contractile response of cells isolated from smooth muscle of the pyloric antrum].

The effect of anti-tissue antisera on the contractile response of isolated smooth muscle cells from rabbit antrum has been investigated. Anti-stomach (SAE), anti-colon (SAC) and anti-diencephale (SAD) antisera induced a dose-dependent contraction is isolated cells, whereas both non-immune serum and antisera obtained by immunization with other foetal tissues were ineffective. Proglumide, the well known gastrin antagonist, similarly inhibited both gastrin- and SAE, SAC, SAD antisera-induced contraction of isolated smooth muscle cells.

Double-blind study on antitissue immunoglobulin injections versus placebo in the treatment of acute lumbar pain with muscular spasms.

A double-blind study was carried out on antitissue immunoglobulins (Sérocytol Neuro-Vasculaire) administered by intradermal injections to 44 patients (24 women, 20 men; age range 36-76 years) suffering from acute lumbar pain accompanied by muscular spasms. In the treated group of 21 patients, excellent or good results were recorded in 14 cases (67%) and moderate results or no effect in 7 (33%). The mean number of injections necessary was 3.