Publications by authors named "P Michon"
: According to the International Working Group on Diabetic Foot (IWGDF) risk classification, the estimated risk of developing a diabetic foot ulcer (DFU) is much higher in patients with a history of DFUs (Grade 3) compared to those with a peripheral neuropathy but without a history of DFUs (Grades 1 and 2). It has been suggested that microcirculation impairment is involved in DFU genesis and could be taken into account to refine the existing risk classification. The aim of this study was to evaluate microcirculation parameters in patients with diabetes according to their estimated DFU risk.
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- Lung adenocarcinoma is a serious cancer that is a major cause of death globally, and this study examines how mitochondrial DNA (mtDNA) copy number impacts tumor growth in mice.
- Increased mtDNA levels were found in lung tumors caused by KRAS expression, leading to larger tumors in mice with higher mtDNA and reduced growth when mtDNA was depleted.
- The findings suggest mtDNA copy number is critical for lung cancer progression and could pave the way for new cancer treatments, while immune responses in the lung remained unaffected by mtDNA levels.
[Orthostatic hypotension: focus on a common pathology sometimes misknowned].
Geriatr Psychol Neuropsychiatr Vieil
December 2022
Orthostatic hypotension is a frequent pathology especially in older adults and inhospital patients. Prevalence is increasing with age, and is about 30 % of patients older than 65 years. Orthostatic hypotension is defined as a fall in blood pressure of at least 20 mmHg systolic or 10 mmHg diastolic when standing or during head-up tilt testing.
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