Ring chromosome 6 may represent a cytogenetic subgroup in benign thymoma.

Cytogenetic and fluorescence in situ hybridization analysis of a thymoma revealed the presence of an abnormal clone with a karyotype 46,XY,r(6)(p2?q35?).ish r(6)(p2?q35?)(WCP6+,dJ476O18-,dJ62I11-, PAC59C23+,PAC57H24-),der(21)t(6;21)(p25;q22)(dJ62I11+,cosC9a1-). Histologically, the tumor was encapsulated and classified as thymoma type AB (World Health Organization classification) or mixed thymoma (Muller-Hermelink classification), composed of well-formed lobules with sharp demarcation of both the spindly type A and lymphocyte-rich type B components.

Monosomy 22 and trisomy 14 may be early events in the tumorigenesis of adult granulosa cell tumor.

The finding of monosomy 22 and trisomy 14 in a case of adult type of granulosa-thecoma cell tumor and the available information from the literature allow for the hypothesis that, especially monosomy 22, but also trisomy 14, may be early events in the tumorigenesis of adult sex cord-stromal tumors in general, and of granulosa-thecoma cell tumors in particular.

Primary malignant melanoma of the larynx. A case report.

Malignant melanoma of the larynx is a rare tumor. Until now only 50 cases have been reported. This article presents a new case of a primary malignant melanoma of the larynx and review of the literature.