Publications by authors named "P Miceli"
Hypopigmentation disorders pose significant diagnostic challenges in dermatology, sometimes reflecting underlying hematological conditions. This review explores the clinical presentations related to hypopigmentation in hematological disorders, focusing on vitiligo, morphea, and syndromic albinism. Vitiligo, an autoimmune disorder targeting melanocytes, involves interactions between genetic polymorphisms and immune responses, particularly regarding CD8+ T cells and IFN-γ.
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- IL-4 and IL-13 play significant roles in the development and symptoms of cutaneous T cell lymphomas (CTCL), particularly in relation to itching (pruritus).
- The transition from a Th1 immune response to a Th2 profile in advanced CTCL may help explain the disease's progression, highlighting the need for early understanding of these interleukins.
- Targeted treatments aimed at blocking IL-4, IL-13, and IL-31 show promise for managing CTCL symptoms and require further investigation through clinical trials to explore their therapeutic potential.
Chemical vapor deposition (CVD) offers a large-area, scalable, and conformal growth of perovskite thin films without the use of solvents. Low-dimensional organic-inorganic halide perovskites, with alternating layers of organic spacer groups and inorganic perovskite layers, are promising for enhancing the stability of optoelectronic devices. Moreover, their multiple quantum-well structures provide a powerful platform for tuning excitonic physics.
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- HLA class II molecules are important in determining susceptibility to autoimmune disorders, especially in skin conditions like psoriasis, but their role in antibody-mediated skin diseases is less understood.
- Research summarized various HLA alleles associated with different blistering skin diseases, highlighting risk alleles like HLA-DQB1*0503 and HLA-DRB1*0402 in pemphigus, HLA-DQB1*0301 in pemphigoid, and strong associations with HLA-DQ2 and HLA-DQ8 in dermatitis herpetiformis.
- Understanding these HLA associations can help in personalized medicine approaches by identifying at-risk individuals who may need to avoid specific disease triggers.