Author Correction: Propagation and Selectivity of Axonal Loss in Leber Hereditary Optic Neuropathy.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Propagation and Selectivity of Axonal Loss in Leber Hereditary Optic Neuropathy.

Leber hereditary optic neuropathy (LHON) is a syndrome of subacute loss of central vision associated with mutations in mitochondrial DNA coding for components of complex I. LHON preferentially involves small axons in the temporal optic nerve, but the reason is unclear. We performed a Monte Carlo simulation of the spread of injury in LHON axons to better understand the predilection for small axons.

An automated cell viability quantification method for low-resolution confocal images of closely packed cells based on a modified gradient flow tracking algorithm.

Fluorescent-based live/dead labelling combined with fluorescent microscopy is one of the widely used and reliable methods for assessment of cell viability. This method is, however, not quantitative. Many image-processing methods have been proposed for cell quantification in an image.

Effect of the slow (K) or rapid (k+) feathering gene on body and feather growth and fatness according to ambient temperature in a Leghorn x brown egg type cross.

Chicks of both sexes issued from the cross of heterozygous K/k+ cocks for the slow-feathering sex linked K allele with k+ (rapid feathering) hens, were compared from the age of 4 to 10 weeks at two ambient temperatures. In individual cages, 30 male chicks of each genotype (K/k+ and k+/k+) were raised at 21 degrees C, and 60 others, distributed in the same way, were raised at 31 degrees C. 71 K/W females and 69 k+/W females were raised in a floor pen at 31 degrees C till 10 weeks of age.

Unmet needs in hypertension: challenges and opportunities.

On the verge of the new millennium, hypertension remains an area of significant unmet medical need. Although progress has been made in the awareness, treatment, and control of hypertension during the last half of the 20th century, recent trends suggest that progress has stalled. Unfavorable trends in awareness and control have been noted by researchers at the Mayo Clinic, in a community that is socioeconomically prosperous with easy access to primary and tertiary medical care.