Publications by authors named "P Melgar Requena"

Introduction: ISMiHealth is a clinical decision support system, integrated as a software tool in the electronic health record system of primary care, that aims to improve the screening performance on infectious diseases and female genital mutilation (FGM) in migrants. The aim of this study is to assess the health impact of the tool and to perform a process evaluation of its feasibility and acceptability when implemented in primary care in Catalonia (Spain).

Methods And Analysis: This study is a cluster randomised control trial where 35 primary care centres in Catalonia, Spain will be allocated into one of the two groups: intervention and control.

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Introduction: Vaccine-induced immunity against COVID-19 generates antibody and lymphocyte responses. However, variability in antibody titers has been observed after vaccination, and the determinants of a better response should be studied. The main objective of this investigation was to analyze the inflammatory biomarker response induced in healthcare workers vaccinated with BNT162b2, and its association with anti-Spike (a SARS-CoV-2 antigen) antibodies measured throughout a 1-year follow-up.

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The relationship between phthalates, a group of chemical pollutants classified as endocrine disruptors, and oxidative stress is not fully understood. The aim of the present hospital-based study was to explore the associations between circulating levels of 10 phthalate metabolites and 8 biomarkers of oxidative stress in adipose tissue. The study population ( = 143) was recruited in two hospitals in the province of Granada (Spain).

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Article Synopsis
  • Chronic malaria infections can lead to T-cell exhaustion, characterized by increased expression of inhibitory markers like PD1, TIM3, and LAG3 in T-cells from exposed individuals.
  • Flow cytometry analysis showed that malaria-exposed pregnant women had higher frequencies of T-cells co-expressing these markers, with significant correlations found between certain T-cell and B-cell populations.
  • Atypical memory B cells (aMBC) were more prevalent in malaria-exposed individuals, correlating inversely with hemoglobin levels, highlighting the impact of chronic malaria on immune responses and potential implications for vaccination strategies.
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Metabolic syndrome is a cluster of conditions that increase the risk of cardiovascular disease, i.e. obesity, insulin resistance, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-c) levels and arterial hypertension.

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