Publications by authors named "P Mela"
Continuous-flow left ventricular assist devices have become an important treatment option for patients with advanced heart failure. However, adverse hemodynamic effects as consequence of an altered blood flow within the aorta and the aortic root remain a topic of concern. In this work, we investigated the influence of the outflow graft orientation on the hemodynamic profile and flow parameters within the thoracic aorta.
View Article and Find Full Text PDFArticle Synopsis
- A new synthetic hydrogel was developed by cross-linking poly(vinylphosphonates) using controlled polymerization methods and photoinitiated thiol-ene click chemistry, allowing for precise adjustments in composition and properties.
- The resulting hydrogels showed increased mechanical strength with more specific monomer units, but reduced water absorption due to increased hydrophobicity; however, functionalization improved water uptake significantly.
- The final hydrogels demonstrated compatibility for cell growth, enabling adhesion of human umbilical artery smooth muscle cells and forming an endothelial layer without inducing inflammatory responses or losing antibacterial properties.
Introduction: The aim of this study was the initial investigation of 4D-Flow MRI and Vector Ultrasound as novel imaging techniques in the in-vitro analysis of hemodynamics in anatomical models. Specifically, by looking at the hemodynamic performance of state-of-the-art surgical heart valves in a 3D-printed aortic arch.
Methods: The mock circulatory loop simulated physiological, pulsatile flow.
Advances in melt electrowriting for cardiovascular applications.
Front Bioeng Biotechnol
September 2024
Article Synopsis
- Melt electrowriting (MEW) is an advanced biofabrication technique using electric fields to create precise microstructures for soft tissue engineering, particularly in cardiovascular applications.
- The method allows for innovative designs, such as introducing microvascular networks, developing small-diameter vascular grafts and stents, and creating adaptable cardiac tissues with customizable properties.
- The overview also highlights ongoing challenges in the field and discusses the latest advancements in biomaterials necessary for fully realizing the potential of MEW technology.
In this in vitro study, the use of a 445 nm diode laser was investigated for the decontamination of titanium dental implants. Different irradiation protocols and the effect of repetitive laser irradiation on temperature increase and decontamination efficacy were evaluated on titanium implant models. An automated setup was developed to realize a scanning procedure for a full surface irradiation to recapitulate a clinical treatment.
View Article and Find Full Text PDF