Interaction of IGF-I and 1 alpha, 25(OH)2D3 on receptor expression and growth stimulation in rat growth plate chondrocytes.

Growth plate cartilage cell express receptors for, and are affected by both IGF-I and 1 alpha, 25(OH)2D3. The studies were undertaken to investigate interaction between these two hormone systems, that is, (i) to study effects of 1 alpha, 25(OH)2D3 on IGF-type 1 receptors (IGFIR), on IGF-I stimulated cell replication, colony formation, and on alkaline phosphatase activity (AP), and conversely, (ii) to study the effect of IGF-I on vitamin D receptor (VDR) expression on 1 alpha, 25(OH)2D3 stimulated growth parameters and on AP activity. Freshly isolated rat tibial chondrocytes were grown in monolayer cultures, (serum-free) or in agarose stabilized suspension cultures (0.

[Perimortal management--humanistic assignment and responsibility. Attempt at status determination].

The scientific research and practical use of all questions concerning life demands interdisciplinary cooperation. This is the result of neglection of death and dying and new social and medical developments as there are institutionalisation of dying and scientific-technical progress. The foundation of the working group "perimortal medicine" in 1983 in the Association for clinical medicine gives the possibility to discuss theoretical and practical questions concerning the end of life, death and dying.

[Diabetes mellitus in advanced age. 6. On the life expectancy following diabetes manifestation (a 23-year mortality follow-up of diabetic patients in a regional district)].

Of all 166 diabetics of all age groups of a rural district detected 23 years ago, the further course of the disease could be followed in 147 patients up to their death and to the present time, respectively. After 8 years 64.6% were still living, after 16 years 29.

[Longevity in patients manifesting diabetes in 1962/1963 in the Neustrelitz district in relation to body weight].

Out of 147 of the 166 diabetics detected in the District of Neustrelitz in 1962/1963 (drop-out rate 11.45%) after 22 years lived still 14.3%.