Isolated Calmness of Perturbation Mappings and Superlinear Convergence of Newton-Type Methods.

In this paper, we characterize Lipschitzian properties of different multiplier-free and multiplier-dependent perturbation mappings associated with the stationarity system of a so-called generalized nonlinear program popularized by Rockafellar. Special emphasis is put on the investigation of the isolated calmness property at and around a point. The latter is decisive for the locally fast convergence of the so-called semismooth* Newton-type method by Gfrerer and Outrata.

First-in-man dose escalation and pharmacokinetic study of CAP7.1, a novel prodrug of etoposide, in adults with refractory solid tumours.

Aim: An open-label, phase I dose-escalation trial was performed in adult patients with various solid cancers to identify the maximum tolerated dose (MTD), to assess the safety, pharmacokinetic profile and anti-tumour activity of the new prodrug CAP7.1. The prodrug is converted to its active moiety etoposide via carboxylesterases in selective cells leading to a better tolerability and higher efficacy in therapeutic resistance cells and children with refractory neuroblastoma.