Myopathy with oval inclusions in a domestic shorthair cat.

Case Summary: An 18-month-old castrated male domestic shorthair cat was presented with a 2-month history of collapse and severe weakness, particularly affecting the pelvic limbs. A biceps femoris muscle biopsy revealed excessive variability in myofibre size, mild necrosis, minimal centronucleation and scattered 10 μm intracytoplasmic oval inclusions. The inclusions appeared amphophilic with haematoxylin and eosin, blue with Gomori trichrome and unstained with nicotinamide adenine dinucleotide dehydrogenase tetrazolium reductase staining.

Evaluation of the Chemotherapy Drug Response Using Organotypic Cultures of Osteosarcoma Tumours from Mice Models and Canine Patients.

Improvements in the clinical outcome of osteosarcoma have plateaued in recent decades with poor translation between preclinical testing and clinical efficacy. Organotypic cultures retain key features of patient tumours, such as a myriad of cell types organized within an extracellular matrix, thereby presenting a more realistic and personalised screening of chemotherapeutic agents ex vivo. To test this concept for the first time in osteosarcoma, murine and canine osteosarcoma organotypic models were maintained for up to 21 days and in-depth analysis identified proportions of immune and stromal cells present at levels comparable to that reported in vivo in the literature.

Pedicle screws implantation in polymethylmethacrylate construct to stabilise sixth lumbar vertebral body fracture in dogs: 5 cases (2015-2018).

Objectives: To assess the feasibility and outcome of pedicle screw implantation on sixth lumbar vertebral body fractures.

Materials And Methods: Dogs with sixth lumbar vertebral body fractures stabilised using L6 and L7 (±L5) pedicular implantation via a dorsal approach preferentially and conventional vertebral body implantation otherwise were reviewed. Coaptation was made with bone cement.

Primary stabilisation for tail avulsion in 15 cats.

Objectives: To evaluate the effects of a primary tail stabilisation technique in relieving pain and supporting nerve recovery in cats that have lost voluntary motor function and pain sensation in the tail without caudal nerve transection.

Materials And Methods: Retrospective review of medical records and preoperative diagnostic tests, including clinical examination results and tail radiographs of cats suffering from tail avulsion with loss of pain perception in the tail between 2009 and 2015. Cats with open tail fracture, tail wounds that necessitated an amputation or caudal nerve root transection were excluded.