Publications by authors named "P McGuffin"

Article Synopsis
  • The study analyzed how often to change antidepressant treatments and aimed to improve predictions about treatment outcomes using ongoing assessments of symptom severity.
  • Participants (n=714) received either escitalopram or nortriptyline for 12 weeks, and remission was defined as a Hamilton Rating Scale score of 7 or lower.
  • Results showed that predictive models based on gathered data, particularly after 4 weeks, could effectively guide treatment decisions, with AUC values indicating good discrimination for the different drugs.
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Background: Although genetic and environmental factors are involved in the aetiology of bipolar disorder [BD], studies focused on their interplay are lacking. The current investigation examines interactions and correlations between polygenic risk scores [PRS] for BD and major depressive disorder [MDD] with stressful life events [SLEs] in liability for BD.

Methods: This study used data from 1715 participants (862 bipolar cases and 853 controls) taken from UK and Canadian samples.

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Background: Personality traits may predict antidepressant discontinuation and response. However, previous studies were rather small, only explored a few personality traits and did not include adverse drug effects nor the interdependency between antidepressant discontinuation patterns and response.

Methods: GENDEP included 589 patients with unipolar moderate-severe depression treated with escitalopram or nortriptyline for 12 weeks.

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