Publications by authors named "P McGettigan"
Background: There is limited evidence to support use of fixed dose combination (FDC) drugs in the treatment of psychiatric disorders. This study aimed to examine the sales and regulatory status of psychotropic FDCs in India, in the context of two government regulatory initiatives.
Methods: Official documents were searched to establish an account of the initiatives and measures targeting psychotropic FDCs.
Background: In randomised controlled trials with efficacy-related primary outcomes, adverse events are collected to monitor potential intervention harms. The analysis of adverse event data is challenging, due to the complex nature of the data and the large number of unprespecified outcomes. This is compounded by a lack of guidance on best analysis approaches, resulting in widespread inadequate practices and the use of overly simplistic methods; leading to sub-optimal exploitation of these rich datasets.
View Article and Find Full Text PDFTemporal Exploration of COPD Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts.
Am J Respir Crit Care Med
September 2024
Background: Chronic obstructive pulmonary disease (COPD) exhibits considerable progression heterogeneity. We hypothesized that elastic principal graph analysis (EPGA) would identify distinct clinical phenotypes and their longitudinal relationships.
Methods: Cross-sectional data from 8,972 tobacco-exposed COPDGene participants, with and without COPD, were used to train a model with EPGA, using thirty clinical, physiologic and CT features.
Background: Incrementing numbers of patients treated for attention-deficit/hyperactivity disorder (ADHD) call for scrutiny concerning long-term drug-safety.
Objectives: This study aims to investigate associations between long-term use of ADHD treatment and cardiovascular outcomes.
Methods: Using nationwide registers, adult patients first-time initiated on ADHD treatment between 1998 and 2020 were identified.