Vaccine against hepatitis B in children: prevention of hepatitis in a pediatric hemodialysis unit.

In a pediatric hemodialysis unit, 10 children (aged 1 to 14 years) with chronic renal failure were immunized against hepatitis B infection (HB) by means of a vaccine. The vaccine was prepared by purification of Hepatitis B surface antigen (HGs Ag) from human sera and was formalin inactivated. Seven children were undergoing periodic hemodialysis and three were still managed with conservative treatment.

[Hepatitis B virus and hepatoma: evidence for a cytoplasmic tumor antigen in transformed hepatocytes].

A tumoural antigen (HBV/T Ag) has been found in the cytoplasm of the human hepatoma cell line PLC/PRF/5 by indirect immunofluorescence and immunoperoxidase assays using anti-sera from Senegalese patients with primary hepatocellular carcinoma. The same antigen was detected in PHC tissues. According to the data obtained with serum and tissue controls the HBV/T Ag-anti-HBV/T system seems associated with transformation of hepatocytes by hepatitis B virus.

[Epidemiology and pathologic results of chronic carriers state of hepatitis B in Mali].

The HB antigen of the hepatitis B (HB) virus, studied by counter immunoelectrophoresis shows a prevalence of 8.7% in 1,860 rural Malians and 11.3% in 764 blood donors from Bamako.

Detection of hepatitis B virus-specific DNA in the genomes of human hepatocellular carcinoma and liver cirrhosis tissues.

Hepatitis B virus-related DNA was detected in the chromosomal DNA of three out of seven hepatocellular carcinomas and two out of five cirrhosis samples examined, by means of the blot-hybridization technique, described by Southern (1975). The integration patterns were not identical but some similarities raise the question of whether there are some preferred sites of viral integration.

Epidemiological and serological study of hepatitis A virus outbreaks in France: a comparison between immunoadherence and radioimmunoassay.

An epidemiological study and the simultaneous evaluation of anti-HAV antibody using radio immunoassay (RIA) and immunoadherence hemagglutination assay (IAHA) was performed during three hepatitis A epidemics in the Tours area (France). Fifty-seven sera from 35 subjects with viral hepatitis type A and 16 sera from nine children who did not develop any clinical signs of hepatitis were studied. The more explosive epidemic occurred in an institution for mentally retarded children (attack rate 68%).